![]() High tidal volume (HTV) ventilation for weaning following CSCI is described to recruit distal airways, stimulate surfactant production, and improve oxygenation. It entails a myriad of complications, and ventilator dependence is one of the most critical. Available from: Ĭervical spinal cord injury (CSCI) imposes a huge health care burden worldwide. ![]() Comparison of Different Tidal Volumes for Ventilation in Patients with an Acute Traumatic Cervical Spine Injury. How to cite this URL: Sengupta D, Bindra A, Kapoor I, Mathur P, Gupta D, Khan MA. How to cite this article: Sengupta D, Bindra A, Kapoor I, Mathur P, Gupta D, Khan MA. Key Message: There is no significant difference in days to achieve ventilator-free breathing, mortality, and duration of hospital stay with HTV (12–15 mL/kg) ventilation compared to LTV (6–8 mL/kg) ventilation in acute CSCI. Keywords: Cervical spine injury, high tidal volume, low tidal volume, ventilation, ventilator-free breathing, weaning No difference in mortality and duration of hospital stay was seen in either group. The PaO 2:FiO 2 ratio was higher with the use of 12–15 mL/kg. There was no significant difference in days to achieve ventilator-free breathing with HTV (12–15 mL/kg) ventilation compared to LTV (6–8 mL/kg) ventilation in acute CSCI. ![]() The duration of hospital stay ( P = 0.2) and mortality ( P = 0.2) was comparable in both groups. The hemodynamic parameters and the vasopressor requirement were comparable in both groups. The median number of days required to achieve VFB was 3 (2, 56) and 8 (2, 50) days, P = 0.33 PaO 2: FIO 2 ratio was 364.0 ± 64 and 321.0 ± 67.0, P = 0.01 the incidence of atelectasis was 25% and 46%, P = 0.16, respectively, in group H and group L. VFB was achieved in 23 and 19 patients in groups H and L, respectively. Patient demographics and injury severity were comparable between the groups. Results and Conclusions: A total of 56 patients, 28 in each group were analyzed. Participants were randomized to receive either HTV, 12–15 mL/kg (group H) or LTV, 6–8 mL/kg (group L) tidal volume ventilation. Materials and Methods: We enrolled patients with acute high traumatic CSCI admitted to the neurotrauma intensive care unit within 24 h of injury, requiring mechanical ventilation. Objective: The aim of this prospective randomized controlled parallel-group, single-blinded study was to compare the effect of two different tidal volumes (12–15 mL/kg and 6–8 mL/kg) in CSCI on days to achieve ventilator-free breathing (VFB), PaO 2/FIO 2 ratio, the incidence of complications, requirement of vasopressor drugs, total duration of hospital stay, and mortality. Source of Support: None, Conflict of Interest: Noneīackground: There is scant literature comparing high tidal volume ventilation (HTV) over low tidal volume (LTV) ventilation in acute traumatic cervical spinal cord injury (CSCI). ![]() Neuroanaesthesiology and Critical Care, Room No 118, Jai Prakash Narayan Apex Trauma Centre (JPNATC), All India Institute of Medical Sciences, New Delhi Comparison of Different Tidal Volumes for Ventilation in Patients with an Acute Traumatic Cervical Spine Injuryĭeep Sengupta 1, Ashish Bindra 2, Indu Kapoor 3, Purva Mathur 4, Deepak Gupta 5, Maroof A Khan 6ġ Neuroanaesthesiology and Critical Care, Max Super Speciality Hospital, Saket, New Delhi, India 2 Neuroanaesthesiology and Critical Care, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India 3 Neuroanaesthesiology and Critical Care, Cardio-Neuro Centre, All India Institute of Medical Sciences, New Delhi, New Delhi, India 4 Microbiology, Lab Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India 5 Department of Neurosurgery, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India 6 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, New Delhi, India
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